ANTIMICROBIAL AND ANTIHYPERLIPIDEMIC ACTIVITIES OF ISOLATED QUERCETIN FROM ANABAENA AEQUALIS
Neveen Abdel-Raouf1, Ibraheem B. M. Ibraheem2,, Sanaa Abdel-Tawab3, Yamna A. G. Naser4
Article first published online: 7 JUL 2011
DOI: 10.1111/j.1529-8817.2011.01020.x
Volume 47, Issue 4, pages 955–962, August 2011
Author Information

  1. 1

Botany and Microbiology Department, Faculty of Science and Medical Studies, Women Students Medical Studies and Sciences Sections, King Saud University for Girls, Riyadh, Saudi Arabia

  1. 2

Botany and Microbiology Department, Faculty of Science, King Saud University, Riyadh, Saudi Arabia

  1. 3

Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt

  1. 4

Botany Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt
Publication History

  1. Issue published online: 25 JUL 2011
  2. Article first published online: 7 JUL 2011
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Keywords:
Anabaena aequalis; antihyperlipidemic agent; antimicrobial activity; cyanobacteria; quercetin
This study aimed to isolate quercetin (for the first time) from Anabaena aequalisBorge, which inhabits soil surface of Wadi El-Alaqui Protectorate located in Aswan city, Egypt. The isolated compound showed significant antibacterial activity against the gram-positive bacteria Sarcina maximaand Micrococcus kristinae,the gram-negative bacterium Klebsiella pneumoniae,as well as against the filamentous fungus Aspergillus flavus. The isolated compound was identified as quercetin using the structure elucidation based on UV, electrospray ionization mass spectrometry (ESIMS), 1H and 13C NMR, proton–proton correlation spectroscopy (1H-1H COSY), distortionless enhancement by polarization transfer (DEPT), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlations spectrum (HMBC). Medium lethal dose (LD50) of the isolated compound and its side effects against hyperlipidemia induced by ethanol intake in albino rats were carried out. No deaths were reported in rats within 72 h, which suggests that the isolated compound plays a beneficial role as an antihyperlipidemic agent in the treatment of alcohol-induced hepatic tissue damage, which can be described as one of the therapeutic values.
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